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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of EDN1 mRNAPMID:22023808
Edn1increases secretionEXP 6480464CTDCisplatin results in increased secretion of EDN1 proteinPMID:28902463
Edn1multiple interactionsEXP 6480464CTDmontelukast inhibits the reaction [Cisplatin results in increased secretion of EDN1 protein]PMID:28902463
Edn1decreases response to substanceISOEDN1 (Homo sapiens)6480464CTDEDN1 results in decreased susceptibility to CisplatinPMID:21656314
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDCisplatin results in increased expression of EDN1 mRNAPMID:21674241
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTDcyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 results in decreased susceptibility to Cisplatin]PMID:21656314
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