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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases expressionEXP 6480464CTDCisplatin results in increased expression of CASP1 proteinPMID:30842369
Casp1increases activityISOCasp1 (Mus musculus)6480464CTDCisplatin results in increased activity of CASP1 proteinPMID:21526214
Casp1increases expressionISOCasp1 (Mus musculus)6480464CTDCisplatin results in increased expression of CASP1 mRNA; Cisplatin results in increased expression of CASP1 proteinPMID:25308879 PMID:26546572 PMID:34423507
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDCisplatin results in increased expression of CASP1 mRNA; Cisplatin results in increased expression of CASP1 proteinPMID:27392435 PMID:34423507
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTD3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of CASP1 mRNA]; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CASP1 mRNA; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP1 protein]PMID:21526214 PMID:23625948 PMID:25308879 PMID:26546572 PMID:34423507
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of CASP1 mRNA; Cisplatin promotes the reaction [jinfukang results in increased expression of CASP1 mRNA]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]; jinfukang promotes the reaction [Cisplatin results in increased expression of CASP1 mRNA]PMID:27392435 PMID:34423507
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