GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp1 | increases expression | EXP | | 6480464 | CTD | Cisplatin results in increased expression of CASP1 protein | PMID:30842369 | Casp1 | increases activity | ISO | Casp1 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased activity of CASP1 protein | PMID:21526214 | Casp1 | increases expression | ISO | Casp1 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased expression of CASP1 mRNA; Cisplatin results in increased expression of CASP1 protein | PMID:25308879 PMID:26546572 PMID:34423507 | Casp1 | increases expression | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased expression of CASP1 mRNA; Cisplatin results in increased expression of CASP1 protein | PMID:27392435 PMID:34423507 | Casp1 | multiple interactions | ISO | Casp1 (Mus musculus) | 6480464 | CTD | 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of CASP1 mRNA]; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CASP1 mRNA; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP1 protein] | PMID:21526214 PMID:23625948 PMID:25308879 PMID:26546572 PMID:34423507 | Casp1 | multiple interactions | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | [Cisplatin co-treated with jinfukang] results in increased expression of CASP1 mRNA; Cisplatin promotes the reaction [jinfukang results in increased expression of CASP1 mRNA]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]; jinfukang promotes the reaction [Cisplatin results in increased expression of CASP1 mRNA] | PMID:27392435 PMID:34423507 | |
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