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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2201
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdkrb2
Name: bradykinin receptor B2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdkrb2decreases expressionISOBDKRB2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of BDKRB2 mRNAPMID:27392435
Bdkrb2decreases response to substanceISOBdkrb2 (Mus musculus)6480464CTDBDKRB2 gene mutant form results in decreased susceptibility to CisplatinPMID:24975837
Bdkrb2increases expressionISOBdkrb2 (Mus musculus)6480464CTDCisplatin results in increased expression of BDKRB2 proteinPMID:31874189
Bdkrb2increases response to substanceISOBdkrb2 (Mus musculus)6480464CTDBDKRB2 gene results in increased susceptibility to CisplatinPMID:24975837
Bdkrb2multiple interactionsISOBdkrb2 (Mus musculus)6480464CTDBDKRB2 gene mutant form inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA]; BDKRB2 gene mutant form inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]PMID:24975837
Bdkrb2multiple interactionsISOBDKRB2 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of BDKRB2 mRNAPMID:27392435
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