• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589591 Species: Rattus norvegicus RGD Object: Gene Symbol: Eif2a Name: eukaryotic translation initiation factor 2A

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1619851	6480464	CTD	Acetylcysteine inhibits the reaction [Cisplatin results in increased phosphorylation of EIF2A protein] Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]]	PMID:21616140
increases phosphorylation	ISO	RGD:1619851	6480464	CTD	Cisplatin results in increased phosphorylation of EIF2A protein	PMID:21616140