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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319072 Species: Homo sapiens RGD Object: Gene Symbol: PRKDC Name: protein kinase, DNA-activated, catalytic polypeptide

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1319073	6480464	CTD	Cisplatin promotes the reaction [PRKDC protein binds to EGFR protein]	PMID:21266349
multiple interactions	EXP		6480464	CTD	PRKDC mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]	PMID:18546291
multiple interactions	ISO	RGD:1319073	6480464	CTD	PRKDC protein mutant form promotes the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] PRKDC protein mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]	PMID:21324906
increases response to substance	ISO	RGD:1319073	6480464	CTD	PRKDC protein mutant form results in increased susceptibility to Cisplatin	PMID:21324906