Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkdc
Name: protein kinase, DNA-activated, catalytic subunit
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkdcincreases expressionISOPRKDC (Homo sapiens)6480464CTDCisplatin results in increased expression of PRKDC mRNAPMID:25450742
Prkdcincreases response to substanceISOPrkdc (Mus musculus)6480464CTDPRKDC protein mutant form results in increased susceptibility to CisplatinPMID:21324906
Prkdcmultiple interactionsISOPRKDC (Homo sapiens)6480464CTD[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PRKDC mRNA; PRKDC mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]PMID:18546291 PMID:30871063
Prkdcmultiple interactionsISOPrkdc (Mus musculus)6480464CTDCisplatin promotes the reaction [PRKDC protein binds to EGFR protein]; PRKDC protein mutant form promotes the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; PRKDC protein mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AX protein]PMID:21266349 PMID:21324906
Go Back to source page   Continue to Ontology report