• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11219 Species: Mus musculus RGD Object: Gene Symbol: Rb1 Name: retinoblastoma 1

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects response to substance	ISO	RGD:731712	6480464	CTD	RB1 protein affects the susceptibility to Cisplatin	PMID:14704340 PMID:17640669
increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of RB1 mRNA	PMID:21151649
affects response to substance	ISO	RGD:731712	6480464	CTD	RB1 protein affects the susceptibility to Cisplatin	PMID:17640669 PMID:14704340