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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185 Species: Rattus norvegicus RGD Object: Gene Symbol: Nos2 Name: nitric oxide synthase 2, inducible

Acc ID: CHEBI:27889 Term: lead(0) Definition: An elemental lead that has formula Pb. CasRN: 7439-92-1 Chemical ID: MESH:D007854

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Vitamin E inhibits the reaction [Lead results in increased expression of NOS2 protein]	PMID:10523326
increases expression	EXP		6480464	CTD	Lead results in increased expression of NOS2 protein	PMID:10523326
increases expression	EXP		6480464	CTD	Lead results in increased expression of NOS2 protein	PMID:10523326 PMID:21364929