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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736925 Species: Homo sapiens RGD Object: Gene Symbol: GJA1 Name: gap junction protein, alpha 1, 43kDa

Acc ID: CHEBI:27881 Term: resveratrol Definition: A stilbenol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2690	6480464	CTD	resveratrol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]	PMID:19720069
decreases expression	ISO	RGD:10649	6480464	CTD	resveratrol results in decreased expression of GJA1 mRNA	PMID:22610192
multiple interactions	ISO	RGD:2690	6480464	CTD	resveratrol affects the phosphorylation of and affects the localization of GJA1 protein resveratrol promotes the reaction [CHRM3 protein binds to GJA1 protein]	PMID:17520802
multiple interactions	ISO	RGD:2690	6480464	CTD	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]	PMID:10973802
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [Glucose results in increased degradation of GJA1 protein]	PMID:20578705