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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3multiple interactionsEXP 6480464CTD[resveratrol co-treated with Dietary Fats] results in decreased phosphorylation of EIF2AK3 proteinPMID:26055348
Eif2ak3increases phosphorylationISOEIF2AK3 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of EIF2AK3 proteinPMID:24264887
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of EIF2AK3 mRNA; Resveratrol inhibits the reaction [Ethanol results in increased expression of EIF2AK3 protein modified form]PMID:23557933 PMID:24224909
Eif2ak3multiple interactionsISOEif2ak3 (Mus musculus)6480464CTDResveratrol inhibits the reaction [Acrolein results in increased phosphorylation of EIF2AK3 protein]; Resveratrol inhibits the reaction [titanium dioxide results in increased expression of EIF2AK3 mRNA]PMID:31298478 PMID:34813903
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