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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621481
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt2
Name: sirtuin 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt2decreases expressionISOSIRT2 (Homo sapiens)6480464CTDresveratrol results in decreased expression of SIRT2 mRNAPMID:21980390
Sirt2increases expressionISOSirt2 (Mus musculus)6480464CTDresveratrol results in increased expression of SIRT2 mRNAPMID:25338179
Sirt2multiple interactionsISOSIRT2 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [TNF protein promotes the reaction [SIRT2 protein binds to IL6 promoter]]PMID:24771768
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