GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prkaa2 | affects response to substance | ISO | Prkaa2 (Mus musculus) | 6480464 | CTD | PRKAA2 protein affects the susceptibility to resveratrol | PMID:23090186 | Prkaa2 | decreases activity | ISO | Prkaa2 (Mus musculus) | 6480464 | CTD | resveratrol results in decreased activity of PRKAA2 protein | PMID:19934007 | Prkaa2 | decreases expression | ISO | Prkaa2 (Mus musculus) | 6480464 | CTD | resveratrol results in decreased expression of PRKAA2 mRNA | PMID:22610192 | Prkaa2 | increases phosphorylation | ISO | PRKAA2 (Homo sapiens) | 6480464 | CTD | resveratrol results in increased phosphorylation of PRKAA2 protein | PMID:18482975 PMID:20080969 | Prkaa2 | increases phosphorylation | ISO | Prkaa2 (Mus musculus) | 6480464 | CTD | resveratrol results in increased phosphorylation of PRKAA2 protein | PMID:17438283 | Prkaa2 | multiple interactions | ISO | PRKAA2 (Homo sapiens) | 6480464 | CTD | [resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides; [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]; [resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of PRKAA2 protein; [resveratrol results in increased phosphorylation of PRKAA2 protein] which results in decreased abundance of Triglycerides; PRKAA2 mutant form inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]; PRKAA2 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased abundance of Triglycerides]]; resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]; resveratrol results in increased phosphorylation of and results in increased activity of PRKAA2 protein; SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]; SIRT1 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA2 protein]; STK11 protein promotes the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein] | PMID:16873680 PMID:18482975 PMID:26044878 | Prkaa2 | multiple interactions | ISO | Prkaa2 (Mus musculus) | 6480464 | CTD | PRKAA2 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]; PRKAA2 protein affects the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; PRKAA2 protein affects the reaction [Resveratrol results in increased cleavage of CASP3 protein]; PRKAA2 protein promotes the reaction [Resveratrol results in increased expression of UCP1 mRNA]; PRKAA2 protein promotes the reaction [Resveratrol results in increased expression of UCP2 mRNA]; PRKAA2 protein promotes the reaction [Resveratrol results in increased expression of UCP3 mRNA]; Resveratrol results in increased phosphorylation of and results in increased activity of PRKAA2 protein; STK11 protein promotes the reaction [Resveratrol results in increased phosphorylation of PRKAA2 protein] | PMID:17438283 PMID:17464184 PMID:19934007 PMID:23090186 PMID:25603053 | | ||||||||||||||||||||||
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