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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDresveratrol results in decreased expression of VEGFA proteinPMID:22050707 PMID:25462211
Vegfaincreases expressionEXP 6480464CTDresveratrol results in increased expression of VEGFA mRNA; resveratrol results in increased expression of VEGFA proteinPMID:16198371 PMID:17188708
Vegfamultiple interactionsEXP 6480464CTD[resveratrol co-treated with plastochromanol 8] results in decreased expression of VEGFA protein; Leuprolide inhibits the reaction [resveratrol results in decreased expression of VEGFA protein]; resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of VEGFA protein]; resveratrol inhibits the reaction [Oxygen results in increased expression of VEGFA protein]; resveratrol inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]]; tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of VEGFA protein]PMID:16198371 PMID:22050707 PMID:22148982 PMID:22191573 PMID:25462211 PMID:26891083
Vegfaaffects expressionISOVEGFA (Homo sapiens)6480464CTDresveratrol affects the expression of VEGFA proteinPMID:17473185
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDresveratrol results in decreased expression of VEGFA mRNA; resveratrol results in decreased expression of VEGFA proteinPMID:15297429 PMID:16227395 PMID:16490592 PMID:17919812 PMID:17935668 PMID:18674879 PMID:20696143 PMID:21209944 PMID:22933405 PMID:24587049 PMID:24901151 PMID:25128170 PMID:26432044 PMID:26911335 PMID:27064016
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDresveratrol results in decreased expression of VEGFA mRNA; resveratrol results in decreased expression of VEGFA proteinPMID:24818384 PMID:25936796
Vegfadecreases response to substanceISOVEGFA (Homo sapiens)6480464CTDresveratrol results in decreased susceptibility to VEGFA protein; VEGFA protein results in decreased susceptibility to resveratrolPMID:16580641 PMID:20012470
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDresveratrol results in decreased secretion of VEGFA proteinPMID:17992120 PMID:22933405 PMID:23536519
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDresveratrol results in increased expression of VEGFA mRNA; resveratrol results in increased expression of VEGFA proteinPMID:16198371 PMID:20021702 PMID:20696143
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDresveratrol results in increased expression of VEGFA proteinPMID:18572362
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Glucose co-treated with resveratrol] results in decreased expression of VEGFA mRNA; [resveratrol results in increased localization of and results in increased activity of CTNNB1 protein] which results in increased expression of VEGFA mRNA; CTNNB1 protein promotes the reaction [resveratrol results in increased expression of VEGFA protein]; resveratrol inhibits the reaction [2,2'-Dipyridyl results in increased activity of VEGFA protein]; resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of VEGFA protein]; resveratrol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; resveratrol inhibits the reaction [CXCL12 protein results in increased secretion of VEGFA protein]; resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]; resveratrol inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA]; resveratrol inhibits the reaction [IGF1 protein results in increased expression of VEGFA protein]; resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of VEGFA protein]; resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; resveratrol inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; resveratrol inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; resveratrol inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; resveratrol results in decreased expression of and results in decreased secretion of VEGFA protein; resveratrol results in increased expression of and results in increased secretion of VEGFA protein; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]]; tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of VEGFA protein]PMID:15297429 PMID:16198371 PMID:16973825 PMID:17919812 PMID:17935668 PMID:18674879 PMID:20578705 PMID:20696143 PMID:20801891 PMID:22314268 PMID:23466666 PMID:24064760 PMID:24895526 PMID:25815440 PMID:26174951
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[Resveratrol co-treated with Praziquantel] results in decreased expression of VEGFA mRNA; [Resveratrol co-treated with Praziquantel] results in decreased expression of VEGFA protein; Fluorouracil promotes the reaction [Resveratrol results in decreased expression of VEGFA protein]; Resveratrol inhibits the reaction [BMP4 protein results in increased expression of VEGFA mRNA]; Resveratrol inhibits the reaction [BMP4 protein results in increased secretion of VEGFA protein]; Resveratrol inhibits the reaction [Calcium Chloride results in increased expression of VEGFA mRNA]; Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of VEGFA protein]; Resveratrol inhibits the reaction [Ethanol results in increased activity of VEGFA protein]; Resveratrol inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Resveratrol promotes the reaction [Fluorouracil results in decreased expression of VEGFA protein]PMID:21086752 PMID:21530968 PMID:22058332 PMID:24435444 PMID:24818384 PMID:25936796 PMID:26221077 PMID:36925030
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