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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prknincreases expressionEXP 6480464CTDResveratrol results in increased expression of PRKN proteinPMID:32619457
Prknmultiple interactionsEXP 6480464CTD[Resveratrol co-treated with Benzo(a)pyrene] results in increased expression of PRKN proteinPMID:32619457
Prknmultiple interactionsISOPRKN (Homo sapiens)6480464CTDPRKN gene mutant form affects the reaction [resveratrol results in increased expression of COX1 mRNA]; PRKN gene mutant form inhibits the reaction [resveratrol results in increased expression of CAT mRNA]; PRKN gene mutant form inhibits the reaction [resveratrol results in increased expression of SOD2 mRNA]; PRKN gene mutant form promotes the reaction [resveratrol results in increased expression of CYCS mRNA]; resveratrol affects the reaction [PRKN gene mutant form affects the expression of PPARGC1A mRNA]; resveratrol affects the reaction [PRKN gene mutant form affects the expression of PPARGC1A protein]PMID:24582596
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