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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D receptor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdrincreases expressionISOVDR (Homo sapiens)6480464CTDresveratrol results in increased expression of VDR mRNA; resveratrol results in increased expression of VDR proteinPMID:12710998 PMID:15280659
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTD[Calcitriol co-treated with resveratrol] results in increased expression of VDR mRNA; ESR1 protein affects the reaction [resveratrol results in increased expression of VDR mRNA]; resveratrol results in increased expression of and results in increased activity of VDR protein; Tamoxifen inhibits the reaction [resveratrol results in increased expression of VDR mRNA]PMID:12710998 PMID:15664452 PMID:16267019
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