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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncamultiple interactionsEXP 6480464CTDResveratrol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]]; Resveratrol inhibits the reaction [MIR141 mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]]PMID:33204711
Sncaaffects bindingISOSNCA (Homo sapiens)6480464CTDresveratrol binds to [SNCA protein binds to SNCA protein]PMID:17597573
Sncaincreases degradationISOSNCA (Homo sapiens)6480464CTDresveratrol results in increased degradation of SNCA proteinPMID:21778691
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTDBECN1 protein affects the reaction [resveratrol results in increased degradation of SNCA protein]PMID:21778691
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