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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca1
Name: BRCA1, DNA repair associated
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1decreases expressionEXP 6480464CTDResveratrol results in decreased expression of BRCA1 mRNAPMID:33775663
Brca1increases expressionEXP 6480464CTDresveratrol results in increased expression of BRCA1 mRNA; resveratrol results in increased expression of BRCA1 proteinPMID:24136580
Brca1multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter]PMID:24136580
Brca1affects localizationISOBRCA1 (Homo sapiens)6480464CTDresveratrol affects the localization of BRCA1 proteinPMID:19559722
Brca1increases expressionISOBRCA1 (Homo sapiens)6480464CTDresveratrol results in increased expression of BRCA1 mRNA; resveratrol results in increased expression of BRCA1 proteinPMID:15149879 PMID:25533949
Brca1multiple interactionsISOBRCA1 (Homo sapiens)6480464CTD[Coumestrol co-treated with Resveratrol] results in increased expression of BRCA1 mRNA; [Estradiol co-treated with Resveratrol] inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]; [Plant Extracts co-treated with Resveratrol] results in increased expression of BRCA1 mRNA; PARP1 protein affects the reaction [Resveratrol results in increased expression of BRCA1 protein]; Resveratrol affects the expression of and affects the phosphorylation of BRCA1 protein; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [AHR protein results in decreased expression of BRCA1]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter]; STF-118804 inhibits the reaction [Resveratrol results in increased expression of BRCA1 protein]PMID:19167446 PMID:19559722 PMID:20631324 PMID:22197621 PMID:23557933 PMID:25533949
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