GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Brca1 | decreases expression | EXP | | 6480464 | CTD | Resveratrol results in decreased expression of BRCA1 mRNA | PMID:33775663 | Brca1 | increases expression | EXP | | 6480464 | CTD | resveratrol results in increased expression of BRCA1 mRNA; resveratrol results in increased expression of BRCA1 protein | PMID:24136580 | Brca1 | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter] | PMID:24136580 | Brca1 | affects localization | ISO | BRCA1 (Homo sapiens) | 6480464 | CTD | resveratrol affects the localization of BRCA1 protein | PMID:19559722 | Brca1 | increases expression | ISO | BRCA1 (Homo sapiens) | 6480464 | CTD | resveratrol results in increased expression of BRCA1 mRNA; resveratrol results in increased expression of BRCA1 protein | PMID:15149879 PMID:25533949 | Brca1 | multiple interactions | ISO | BRCA1 (Homo sapiens) | 6480464 | CTD | [Coumestrol co-treated with Resveratrol] results in increased expression of BRCA1 mRNA; [Estradiol co-treated with Resveratrol] inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]; [Plant Extracts co-treated with Resveratrol] results in increased expression of BRCA1 mRNA; PARP1 protein affects the reaction [Resveratrol results in increased expression of BRCA1 protein]; Resveratrol affects the expression of and affects the phosphorylation of BRCA1 protein; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [AHR protein results in decreased expression of BRCA1]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter]; STF-118804 inhibits the reaction [Resveratrol results in increased expression of BRCA1 protein] | PMID:19167446 PMID:19559722 PMID:20631324 PMID:22197621 PMID:23557933 PMID:25533949 | |
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