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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007 Species: Homo sapiens RGD Object: Gene Symbol: CYP2E1 Name: cytochrome P450, family 2, subfamily E, polypeptide 1

Acc ID: CHEBI:27881 Term: resveratrol Definition: A stilbenol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:10451	6480464	CTD	resveratrol results in increased expression of CYP2E1 mRNA	PMID:22610192
decreases activity	ISO	RGD:10451	6480464	CTD	resveratrol analog results in decreased activity of CYP2E1 protein	PMID:16684708
affects expression	ISO	RGD:2475	6480464	CTD	resveratrol affects the expression of CYP2E1 mRNA	PMID:15748624
multiple interactions	ISO	RGD:10451	6480464	CTD	resveratrol inhibits the reaction [Pyrogallol results in increased activity of CYP2E1 protein] resveratrol inhibits the reaction [Pyrogallol results in increased expression of CYP2E1 mRNA]	PMID:18789925
decreases activity	ISO	RGD:10451	6480464	CTD	resveratrol results in decreased activity of CYP2E1 protein	PMID:18420780