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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chukdecreases phosphorylationISOCHUK (Homo sapiens)6480464CTDresveratrol results in decreased phosphorylation of CHUK proteinPMID:25692777
Chukmultiple interactionsISOCHUK (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with Resveratrol] results in decreased expression of CHUK mRNA; [Plant Extracts co-treated with Resveratrol] results in increased expression of CHUK mRNA; Resveratrol inhibits the reaction [Niacinamide results in increased activity of CHUK protein]; Resveratrol inhibits the reaction [TNF protein results in increased activity of CHUK protein]PMID:15489888 PMID:23557933 PMID:24289642 PMID:24962570
Chukmultiple interactionsISOChuk (Mus musculus)6480464CTDresveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]PMID:16474181 PMID:22118570
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