Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2143
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp4
Name: aquaporin 4
Acc ID: CHEBI:27789
Term: 1,2-dichloroethane
Definition: A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.
Chemical ID: MESH:C024565
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp4decreases expressionEXP 6480464CTDethylene dichloride results in decreased expression of AQP4 mRNA; ethylene dichloride results in decreased expression of AQP4 proteinPMID:31734271
Aqp4affects response to substanceISOAqp4 (Mus musculus)6480464CTDAQP4 protein affects the susceptibility to ethylene dichloridePMID:31734271
Aqp4decreases expressionISOAqp4 (Mus musculus)6480464CTDethylene dichloride results in decreased expression of AQP4 mRNA; ethylene dichloride results in decreased expression of AQP4 proteinPMID:31734271
Aqp4increases expressionISOAqp4 (Mus musculus)6480464CTDethylene dichloride results in increased expression of AQP4 mRNA; ethylene dichloride results in increased expression of AQP4 proteinPMID:24964198
Aqp4increases expressionISOAQP4 (Homo sapiens)6480464CTDethylene dichloride results in increased expression of AQP4 mRNA; ethylene dichloride results in increased expression of AQP4 proteinPMID:37028497
Aqp4multiple interactionsISOAqp4 (Mus musculus)6480464CTD[ethylene dichloride co-treated with Ethanol] results in decreased expression of AQP4 mRNA; [ethylene dichloride co-treated with Ethanol] results in decreased expression of AQP4 proteinPMID:30664321
Go Back to source page   Continue to Ontology report