GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Glyphosate affects the expression of ESR1 protein | PMID:27463640 | Esr1 | affects expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Glyphosate affects the expression of ESR1 mRNA | PMID:35457321 | Esr1 | affects splicing | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Glyphosate affects the splicing of ESR1 mRNA | PMID:30447247 | Esr1 | decreases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Glyphosate results in decreased expression of ESR1 mRNA; Glyphosate results in decreased expression of ESR1 protein | PMID:27463640 PMID:27486271 PMID:30447247 | Esr1 | decreases methylation | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Glyphosate results in decreased methylation of ESR1 promoter | PMID:30391669 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Glyphosate results in increased activity of ESR1 protein | PMID:28711546 | Esr1 | increases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Glyphosate results in increased expression of ESR1 mRNA; Glyphosate results in increased expression of ESR1 mRNA alternative form; Glyphosate results in increased expression of ESR1 protein | PMID:27287056 PMID:29746933 PMID:30391669 PMID:31550491 PMID:32640336 PMID:34906888 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Glyphosate results in increased expression of ESR1 mRNA; Glyphosate results in increased expression of ESR1 protein | PMID:23756170 PMID:29890199 | Esr1 | increases methylation | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | Glyphosate results in increased methylation of ESR1 promoter | PMID:30447247 | Esr1 | increases response to substance | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | ESR1 protein results in increased susceptibility to Glyphosate | PMID:29890199 | Esr1 | multiple interactions | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | [Glyphosate results in increased methylation of ESR1 promoter] which affects the splicing of ESR1 mRNA; Fulvestrant inhibits the reaction [Glyphosate results in increased expression of ESR1 protein] | PMID:30447247 PMID:34906888 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [afimoxifene results in decreased susceptibility to Glyphosate] which results in increased expression of ESR1 protein modified form; [Glyphosate co-treated with Herbicides] results in decreased activity of ESR1 protein; [Glyphosate results in increased abundance of aminomethylphosphonic acid (AMPA)] which affects the methylation of ESR1 promoter; afimoxifene inhibits the reaction [Glyphosate results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Glyphosate results in increased activity of ESR1 protein] | PMID:19539684 PMID:28711546 PMID:29890199 PMID:35377194 | |
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