Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDGlyphosate affects the expression of ESR1 proteinPMID:27463640
Esr1affects expressionISOESR1 (Homo sapiens)6480464CTDGlyphosate affects the expression of ESR1 mRNAPMID:35457321
Esr1affects splicingISOEsr1 (Rattus norvegicus)6480464CTDGlyphosate affects the splicing of ESR1 mRNAPMID:30447247
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDGlyphosate results in decreased expression of ESR1 mRNA; Glyphosate results in decreased expression of ESR1 proteinPMID:27463640 PMID:27486271 PMID:30447247
Esr1decreases methylationISOEsr1 (Rattus norvegicus)6480464CTDGlyphosate results in decreased methylation of ESR1 promoterPMID:30391669
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDGlyphosate results in increased activity of ESR1 proteinPMID:28711546
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDGlyphosate results in increased expression of ESR1 mRNA; Glyphosate results in increased expression of ESR1 mRNA alternative form; Glyphosate results in increased expression of ESR1 proteinPMID:27287056 PMID:29746933 PMID:30391669 PMID:31550491 PMID:32640336 PMID:34906888
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDGlyphosate results in increased expression of ESR1 mRNA; Glyphosate results in increased expression of ESR1 proteinPMID:23756170 PMID:29890199
Esr1increases methylationISOEsr1 (Rattus norvegicus)6480464CTDGlyphosate results in increased methylation of ESR1 promoterPMID:30447247
Esr1increases response to substanceISOESR1 (Homo sapiens)6480464CTDESR1 protein results in increased susceptibility to GlyphosatePMID:29890199
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[Glyphosate results in increased methylation of ESR1 promoter] which affects the splicing of ESR1 mRNA; Fulvestrant inhibits the reaction [Glyphosate results in increased expression of ESR1 protein]PMID:30447247 PMID:34906888
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[afimoxifene results in decreased susceptibility to Glyphosate] which results in increased expression of ESR1 protein modified form; [Glyphosate co-treated with Herbicides] results in decreased activity of ESR1 protein; [Glyphosate results in increased abundance of aminomethylphosphonic acid (AMPA)] which affects the methylation of ESR1 promoter; afimoxifene inhibits the reaction [Glyphosate results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Glyphosate results in increased activity of ESR1 protein]PMID:19539684 PMID:28711546 PMID:29890199 PMID:35377194
Go Back to source page   Continue to Ontology report