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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adora1
Name: adenosine A1 receptor
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora1decreases activityEXP 6480464CTDCaffeine results in decreased activity of ADORA1 proteinPMID:15708489
Adora1decreases expressionEXP 6480464CTDCaffeine results in decreased expression of ADORA1 mRNAPMID:12153486
Adora1multiple interactionsEXP 6480464CTDCaffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]; Caffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]PMID:10401785 PMID:3003150
Adora1decreases activityISOADORA1 (Homo sapiens)6480464CTDCaffeine results in decreased activity of ADORA1 proteinPMID:23611293
Adora1decreases activityISOAdora1 (Mus musculus)6480464CTDCaffeine results in decreased activity of ADORA1 proteinPMID:22164264
Adora1decreases expressionISOAdora1 (Mus musculus)6480464CTDCaffeine deficiency results in decreased expression of ADORA1 mRNAPMID:29107002
Adora1increases expressionISOAdora1 (Mus musculus)6480464CTDCaffeine results in increased expression of ADORA1 proteinPMID:7996441
Adora1multiple interactionsISOAdora1 (Mus musculus)6480464CTD[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine; [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA; [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNAPMID:29107002 PMID:29882086 PMID:7996441
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