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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730895 Species: Mus musculus RGD Object: Gene Symbol: Il18 Name: interleukin 18

Acc ID: CHEBI:27584 Term: aldosterone Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. CasRN: 52-39-1 Chemical ID: MESH:D000450

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:2889	6480464	CTD	Aldosterone results in increased expression of IL18 protein Aldosterone results in increased expression of IL18 mRNA	PMID:18660453
multiple interactions	ISO	RGD:2889	6480464	CTD	Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] Cycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] pioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] SN50 peptide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] exoenzyme C3, Clostridium botulinum inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]	PMID:18660453