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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2454 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp11b2 Name: cytochrome P450, family 11, subfamily b, polypeptide 2

Acc ID: CHEBI:27584 Term: aldosterone Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. CasRN: 52-39-1 Chemical ID: MESH:D000450

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects chemical synthesis	ISO	RGD:736494	6480464	CTD	CYP11B2 protein affects the chemical synthesis of Aldosterone	PMID:12525251
increases chemical synthesis	ISO	RGD:736494	6480464	CTD	CYP11B2 protein polymorphism results in increased chemical synthesis of Aldosterone	PMID:12783697
increases chemical synthesis	ISO	RGD:736494	6480464	CTD	CYP11B2 protein results in increased chemical synthesis of Aldosterone	PMID:16054388
affects chemical synthesis	ISO	RGD:10430	6480464	CTD	CYP11B2 protein affects the chemical synthesis of Aldosterone	PMID:15731365
affects chemical synthesis	EXP		6480464	CTD	CYP11B2 protein affects the chemical synthesis of Aldosterone	PMID:16043663
increases chemical synthesis	ISO	RGD:736494	6480464	CTD	CYP11B2 protein results in increased chemical synthesis of Aldosterone	PMID:16054388 PMID:19900470