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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735269 Species: Homo sapiens RGD Object: Gene Symbol: DIO1 Name: deiodinase, iodothyronine, type I

Acc ID: CHEBI:27568 Term: selenium atom Definition: A chalcogen that has formula Se. CasRN: 7782-49-2 Chemical ID: MESH:D012643

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:10474	6480464	CTD	Selenium deficiency results in decreased expression of DIO1 mRNA	PMID:16170372
multiple interactions	ISO	RGD:10474	6480464	CTD	Selenium inhibits the reaction [Iodine results in decreased activity of DIO1 protein] Selenium inhibits the reaction [Iodine results in decreased expression of DIO1 mRNA]	PMID:17044649
multiple interactions	ISO	RGD:10474	6480464	CTD	Selenium inhibits the reaction [potassium iodate results in decreased activity of DIO1 protein]	PMID:18095564
increases activity	ISO	RGD:10474	6480464	CTD	Selenium results in increased activity of DIO1 protein	PMID:16959840
increases activity	ISO	RGD:2504	6480464	CTD	Selenium results in increased activity of DIO1 protein	PMID:16271152
affects expression	ISO	RGD:2504	6480464	CTD	Selenium deficiency affects the expression of DIO1 mRNA	PMID:16874406
increases expression	ISO	RGD:2504	6480464	CTD	Selenium results in increased expression of DIO1 mRNA	PMID:16271152