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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:27568
Term: selenium atom
Definition: A chalcogen that has formula Se.
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTD[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA]; Selenium inhibits the reaction [Cadmium Chloride results in increased expression of TP53 protein]PMID:16600092 PMID:21628957
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDSelenium results in decreased expression of TP53 proteinPMID:17523932
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDSelenium results in increased expression of TP53 mRNAPMID:19244175
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of TP53 mRNA]; [Selenium co-treated with Vitamin E] results in increased expression of TP53 mRNAPMID:19244175 PMID:27920530
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