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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736273 Species: Homo sapiens RGD Object: Gene Symbol: TGFA Name: transforming growth factor, alpha

Acc ID: CHEBI:27563 Term: arsenic atom Definition: A pnictogen that has formula As. CasRN: 7440-38-2 Chemical ID: MESH:D001151

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Arsenic results in increased expression of TGFA mRNA	PMID:19945496
multiple interactions	EXP		6480464	CTD	[Arsenic co-treated with Fluorides] results in decreased expression of TGFA mRNA	PMID:19962721
decreases expression	EXP		6480464	CTD	Arsenic results in decreased expression of TGFA mRNA	PMID:19962721
increases expression	EXP		6480464	CTD	Arsenic results in increased expression of TGFA protein	PMID:17056473