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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620786
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Msh2
Name: mutS homolog 2
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Msh2affects expressionISOMSH2 (Homo sapiens)6480464CTDArsenic affects the expression of MSH2 mRNAPMID:17450239
Msh2increases methylationISOMSH2 (Homo sapiens)6480464CTDArsenic results in increased methylation of MSH2 promoterPMID:29499398
Msh2multiple interactionsISOMSH2 (Homo sapiens)6480464CTD[Arsenic results in increased methylation of MSH2 promoter] which results in decreased expression of MSH2 mRNAPMID:29499398
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