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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2287 Species: Rattus norvegicus RGD Object: Gene Symbol: Cbs Name: cystathionine beta synthase

Acc ID: CHEBI:27563 Term: arsenic atom Definition: A pnictogen that has formula As. CasRN: 7440-38-2 Chemical ID: MESH:D001151

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:737316	6480464	CTD	Arsenic results in increased expression of CBS mRNA	PMID:18487201
affects metabolic processing	ISO	RGD:737316	6480464	CTD	CBS gene SNP affects the metabolism of Arsenic	PMID:20600216
affects metabolic processing	ISO	RGD:737316	6480464	CTD	CBS gene polymorphism affects the metabolism of Arsenic	PMID:20670920
affects response to substance	ISO	RGD:737316	6480464	CTD	CBS gene polymorphism affects the susceptibility to Arsenic	PMID:20670920