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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:27510
Term: umbelliferone
Definition: A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.
Chemical ID: MESH:C031477
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases expressionEXP 6480464CTD7-hydroxycoumarin results in increased expression of NFE2L2 mRNA; 7-hydroxycoumarin results in increased expression of NFE2L2 proteinPMID:33522649
Nfe2l2multiple interactionsEXP 6480464CTD7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]PMID:33522649
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTD7-hydroxycoumarin results in increased expression of NFE2L2 mRNAPMID:28263721
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD7-hydroxycoumarin results in increased expression of and affects the localization of NFE2L2 proteinPMID:28263721
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