GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects activity | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mitomycin affects the activity of TP53 protein | PMID:35435491 | Tp53 | affects localization | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mitomycin affects the localization of TP53 protein | PMID:35882637 | Tp53 | affects response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein affects the susceptibility to Mitomycin | PMID:15182437 PMID:20000476 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mitomycin results in increased expression of TP53; Mitomycin results in increased expression of TP53 mRNA; Mitomycin results in increased expression of TP53 protein; Mitomycin results in increased expression of TP53 protein modified form | PMID:12082016 PMID:16186332 PMID:18647660 PMID:19834285 PMID:24675086 PMID:34624459 | Tp53 | increases stability | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mitomycin results in increased stability of TP53 protein | PMID:20536192 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [Mitomycin results in increased stability of TP53 protein] which results in increased expression of CDKN1A mRNA; [Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA; Mitomycin promotes the reaction [TP53 protein results in increased expression of CCNB1 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of DDB2 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of GADD45A mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of HSPA8 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of PCNA mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of SGK1 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of TP53I3 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of TRIAP1 mRNA]; Mitomycin results in increased phosphorylation of and results in increased activity of TP53 protein; Silybin inhibits the reaction [Mitomycin results in increased expression of TP53]; TP53 protein affects the reaction [Mitomycin results in increased activity of GLB1 protein]; TP53 protein affects the reaction [Mitomycin results in increased expression of CDKN1A protein]; TRP53 protein affects the reaction [Mitomycin results in increased expression of TRP73 protein] | PMID:17530733 PMID:18647660 PMID:19834285 PMID:20536192 PMID:24675086 PMID:34624459 | | ||||||||||||||||||||||
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