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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566323 Species: Rattus norvegicus RGD Object: Gene Symbol: Fan1 Name: FANCD2/FANCI-associated nuclease 1

Acc ID: CHEBI:27504 Term: mitomycin C Definition: A mitomycin that has formula C15H18N4O5. CasRN: 50-07-7 Chemical ID: MESH:D016685

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases response to substance	ISO	RGD:1604829	6480464	CTD	FAN1 protein results in decreased susceptibility to Mitomycin	PMID:21115814
increases response to substance	ISO	RGD:1604829	6480464	CTD	FAN1 gene mutant form results in increased susceptibility to Mitomycin	PMID:22772369