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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:27504
Term: mitomycin C
Definition: A mitomycin that has formula C15H18N4O5.
Chemical ID: MESH:D016685
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDMitomycin results in increased expression of H2AX protein; Mitomycin results in increased expression of H2AX protein modified formPMID:29928969 PMID:32087850
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDMitomycin results in increased phosphorylation of H2AX proteinPMID:21386838 PMID:32482060 PMID:34510228
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