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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520 Species: Mus musculus RGD Object: Gene Symbol: Cyp19a1 Name: cytochrome P450, family 19, subfamily a, polypeptide 1

Acc ID: CHEBI:27496 Term: simazine Definition: A chloro-1,3,5-triazine herbicide that has formula C7H12ClN5. CasRN: 122-34-9 Chemical ID: MESH:D012839

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1606587	6480464	CTD	formestane inhibits the reaction [Simazine results in increased activity of CYP19A1 protein]	PMID:10746939
increases activity	ISO	RGD:1606587	6480464	CTD	Simazine results in increased activity of CYP19A1 protein	PMID:11675267 PMID:10746939
increases expression	ISO	RGD:1606587	6480464	CTD	Simazine results in increased expression of CYP19A1 mRNA	PMID:10746939 PMID:11675267
increases activity	ISO	RGD:1606587	6480464	CTD	Simazine results in increased activity of CYP19A1 protein	PMID:10746939 PMID:11675267
increases expression	ISO	RGD:1606587	6480464	CTD	Simazine results in increased expression of CYP19A1 mRNA	PMID:11675267 PMID:10746939