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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072 Species: Homo sapiens RGD Object: Gene Symbol: VEGFA Name: vascular endothelial growth factor A

Acc ID: CHEBI:27470 Term: folic acid Definition: Folic acid is a form of the water-soluble vitamine B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. CasRN: 59-30-3 Chemical ID: MESH:D005492

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:731073	6480464	CTD	Folic Acid results in decreased expression of VEGFA protein Folic Acid results in decreased expression of VEGFA mRNA	PMID:14633603
affects expression	EXP		6480464	CTD	Folic Acid affects the expression of VEGFA mRNA	PMID:16361273
multiple interactions	ISO	RGD:731073	6480464	CTD	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of VEGFA gene [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of VEGFA	PMID:20938992