GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | increases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Folic Acid results in increased expression of TGFB1 mRNA; Folic Acid results in increased expression of TGFB1 protein | PMID:24275386 PMID:29380373 PMID:30405444 | Tgfb1 | multiple interactions | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Folic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]; Folic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 mRNA]; Folic Acid inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Folic Acid inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Folic Acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; Folic Acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; Folic Acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] | PMID:29380373 | Tgfb1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFB1 gene; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 protein] | PMID:20938992 PMID:29380373 | |
Go Back to source page | Continue to Ontology report |