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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62281 Species: Mus musculus RGD Object: Gene Symbol: Ankrd1 Name: ankyrin repeat domain 1 (cardiac muscle)

Acc ID: CHEBI:27470 Term: folic acid Definition: Folic acid is a form of the water-soluble vitamine B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. CasRN: 59-30-3 Chemical ID: MESH:D005492

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1348352	6480464	CTD	Folic Acid results in increased expression of ANKRD1 mRNA	PMID:17868486
multiple interactions	EXP		6480464	CTD	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANKRD1 mRNA	PMID:20938992