• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346305 Species: Homo sapiens RGD Object: Gene Symbol: FOLR1 Name: folate receptor 1 (adult)

Acc ID: CHEBI:27470 Term: folic acid Definition: Folic acid is a form of the water-soluble vitamine B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. CasRN: 59-30-3 Chemical ID: MESH:D005492

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	Folic Acid affects the expression of FOLR1 mRNA	PMID:17311948
decreases expression	EXP		6480464	CTD	Folic Acid results in decreased expression of FOLR1 mRNA	PMID:17616776
affects abundance	ISO	RGD:734402	6480464	CTD	FOLR1 protein affects the abundance of Folic Acid	PMID:15705887
increases uptake	ISO	RGD:734402	6480464	CTD	FOLR1 protein results in increased uptake of Folic Acid	PMID:14581169
multiple interactions	ISO	RGD:734402	6480464	CTD	RFC1 protein mutant form promotes the reaction [FOLR1 protein mutant form results in decreased abundance of Folic Acid]	PMID:18926688
decreases expression	ISO	RGD:71032	6480464	CTD	Folic Acid results in decreased expression of FOLR1 protein	PMID:17482424
decreases abundance	EXP		6480464	CTD	FOLR1 gene mutant form results in decreased abundance of Folic Acid	PMID:19732866
increases transport	EXP		6480464	CTD	FOLR1 protein results in increased transport of Folic Acid	PMID:19732866