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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:27436
Term: methyltestosterone
Definition: A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.
Chemical ID: MESH:D008777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityISOEsr1 (Rattus norvegicus)6480464CTDMethyltestosterone results in increased activity of ESR1 proteinPMID:12504345
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDMethyltestosterone results in increased expression of ESR1 proteinPMID:38133387
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDMethyltestosterone binds to and results in increased activity of ESR1 protein; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Methyltestosterone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]PMID:23383871 PMID:25012808 PMID:29162470 PMID:33049310
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