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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814 Species: Mus musculus RGD Object: Gene Symbol: Bnip3 Name: BCL2/adenovirus E1B interacting protein 3

Acc ID: CHEBI:27385 Term: tetrachloromethane Definition: A chloromethane that has formula CCl4. CasRN: 56-23-5 Chemical ID: MESH:D002251

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Carbon Tetrachloride results in decreased expression of BNIP3 mRNA	PMID:17084009
multiple interactions	EXP		6480464	CTD	CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of BNIP3 mRNA]	PMID:17084009
increases expression	EXP		6480464	CTD	Carbon Tetrachloride results in increased expression of BNIP3 mRNA	PMID:17484886
affects expression	ISO	RGD:620800	6480464	CTD	Carbon Tetrachloride affects the expression of BNIP3 mRNA	PMID:15963342