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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731035 Species: Homo sapiens RGD Object: Gene Symbol: SPARC Name: secreted protein, acidic, cysteine-rich (osteonectin)

Acc ID: CHEBI:27385 Term: tetrachloromethane Definition: A chloromethane that has formula CCl4. CasRN: 56-23-5 Chemical ID: MESH:D002251

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:3742	6480464	CTD	Carbon Tetrachloride results in increased expression of SPARC mRNA	PMID:17056239 PMID:16239168
affects expression	ISO	RGD:11336	6480464	CTD	Carbon Tetrachloride affects the expression of SPARC mRNA	PMID:17484886
increases expression	ISO	RGD:3742	6480464	CTD	Carbon Tetrachloride results in increased expression of SPARC mRNA	PMID:16239168 PMID:17056239