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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62252 Species: Mus musculus RGD Object: Gene Symbol: Txnrd1 Name: thioredoxin reductase 1

Acc ID: CHEBI:27385 Term: tetrachloromethane Definition: A chloromethane that has formula CCl4. CasRN: 56-23-5 Chemical ID: MESH:D002251

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	EXP		6480464	CTD	Carbon Tetrachloride results in increased activity of TXNRD1 protein	PMID:18215477
decreases expression	ISO	RGD:61959	6480464	CTD	Carbon Tetrachloride results in decreased expression of TXNRD1 mRNA	PMID:17522070
increases expression	ISO	RGD:61959	6480464	CTD	Carbon Tetrachloride results in increased expression of TXNRD1 mRNA	PMID:17202758