GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | decreases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of VEGFA mRNA | PMID:16239168 | Vegfa | increases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of VEGFA mRNA; Carbon Tetrachloride results in increased expression of VEGFA protein | PMID:10613739 PMID:16644059 PMID:17631135 PMID:23845850 PMID:35236242 | Vegfa | multiple interactions | EXP | | 6480464 | CTD | 1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of VEGFA protein]; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of VEGFA protein; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein] | PMID:23845850 PMID:28693887 PMID:35236242 | Vegfa | increases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of VEGFA mRNA; Carbon Tetrachloride results in increased expression of VEGFA protein | PMID:24646716 PMID:33549628 | Vegfa | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of VEGFA mRNA; ADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; ADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein]; ATG5 protein inhibits the reaction [curcumol inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein]]; ATG5 protein promotes the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein]; curcumol inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein]; KLF5 protein inhibits the reaction [curcumol inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein]]; KLF5 protein promotes the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein] | PMID:24646716 PMID:26778414 PMID:33549628 | | ||||||||||||||||||||||
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