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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619893
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plg
Name: plasminogen
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plgaffects expressionEXP 6480464CTDCarbon Tetrachloride affects the expression of PLG mRNAPMID:12734012
Plgdecreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of PLG mRNAPMID:30723492 PMID:31150632
Plgmultiple interactionsEXP 6480464CTDschizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PLG mRNA]PMID:31150632
Plgaffects response to substanceISOPlg (Mus musculus)6480464CTDPLG protein affects the susceptibility to Carbon TetrachloridePMID:16006527
Plgmultiple interactionsISOPlg (Mus musculus)6480464CTDPLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AMY2A5 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AURKA mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2A1D mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL6 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNA2 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB2 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CELA1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CELA2A mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CHIL3 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CTDSP2 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of DBP mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of EGR1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ELOVL6 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of GSTM3 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of KIF22 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LCN2 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LPL mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MARCO mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NNMT mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PALD1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PLK1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PMF1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PNLIPRP1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PRSS2 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTTG1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SAA1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SLC51A mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of STMN1 mRNA]; PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TRY4 mRNA]; PLG protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2L11 protein]; PLG protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]; PLG protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]; PLG protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]PMID:14716496 PMID:16006527 PMID:17482686
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