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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases activityEXP 6480464CTDCarbon Tetrachloride results in decreased activity of NOS3 proteinPMID:12943827
Nos3decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of NOS3 proteinPMID:12575897
Nos3decreases phosphorylationEXP 6480464CTDCarbon Tetrachloride results in decreased phosphorylation of NOS3 proteinPMID:12891555
Nos3increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of NOS3 mRNA; Carbon Tetrachloride results in increased expression of NOS3 proteinPMID:16325526 PMID:16644059
Nos3multiple interactionsEXP 6480464CTDAKT1 protein inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of NOS3 protein]; Carbon Tetrachloride results in decreased phosphorylation of and results in decreased activity of NOS3 protein; Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein; wortmannin affects the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein]PMID:12891555 PMID:18245901 PMID:18317400
Nos3decreases expressionISONos3 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of NOS3 mRNA; Carbon Tetrachloride results in decreased expression of NOS3 proteinPMID:18429990
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