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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects expressionEXP 6480464CTDCarbon Tetrachloride affects the expression of CYP1A2 mRNAPMID:15963342
Cyp1a2decreases activityEXP 6480464CTDCarbon Tetrachloride results in decreased activity of CYP1A2 proteinPMID:14706259 PMID:16288784
Cyp1a2decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of CYP1A2 mRNA; Carbon Tetrachloride results in decreased expression of CYP1A2 proteinPMID:14706259 PMID:16239168 PMID:17606319 PMID:20930465 PMID:31150632
Cyp1a2increases metabolic processingEXP 6480464CTDCYP1A2 protein results in increased metabolism of Carbon TetrachloridePMID:15988118
Cyp1a2multiple interactionsEXP 6480464CTD2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline promotes the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 protein]; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Carbon Tetrachloride] results in increased expression of CYP1A2 mRNA; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 mRNA]PMID:16288784 PMID:20930465 PMID:31150632
Cyp1a2decreases expressionISOCyp1a2 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of CYP1A2 mRNA; Carbon Tetrachloride results in decreased expression of CYP1A2 proteinPMID:16445600 PMID:17084009 PMID:18038451 PMID:27339419 PMID:31919559 PMID:32063085
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of CYP1A2 mRNA; Carbon Tetrachloride results in increased expression of CYP1A2 proteinPMID:24646716
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CYP1A2 mRNA; ADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of CYP1A2 mRNA]; ADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of CYP1A2 protein]; AK-1 compound inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 mRNA]; CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 mRNA]PMID:17084009 PMID:24646716 PMID:30517762 PMID:32063085
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