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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtincreases localizationEXP 6480464CTDAGT protein results in increased localization of ZincPMID:22427991
Agtmultiple interactionsEXP 6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in increased localization of Zinc]; Zinc inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Zinc inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Zinc promotes the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Zinc promotes the reaction [AGT protein results in increased phosphorylation of AKT1 protein]PMID:22427991
Agtaffects bindingISOAGT (Homo sapiens)6480464CTDAGT protein binds to ZincPMID:23896426
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