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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2462
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Acc ID: CHEBI:27300
Term: vitamin D
Definition: Any member of a group of fat-soluble hydroxy seco-steroids that exhibit biological activity against vitamin D deficiency. Vitamin D can be obtained from sun exposure, food and supplements and is biologically inactive and converted into the biologically active calcitriol via double hydroxylation in the body.
Chemical ID: MESH:D014807
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp24a1decreases expressionEXP 6480464CTDVitamin D deficiency results in decreased expression of CYP24A1 proteinPMID:8410379
Cyp24a1multiple interactionsEXP 6480464CTDVitamin D inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]PMID:17535892
Cyp24a1increases expressionISOCYP24A1 (Homo sapiens)6480464CTDVitamin D analog results in increased expression of CYP24A1 mRNA; Vitamin D results in increased expression of CYP24A1 mRNAPMID:20055894 PMID:21917910
Cyp24a1increases expressionISOCyp24a1 (Mus musculus)6480464CTDVitamin D results in increased expression of CYP24A1 mRNAPMID:22892342
Cyp24a1multiple interactionsISOCYP24A1 (Homo sapiens)6480464CTDLithocholic Acid inhibits the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]; Vitamin D analog inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Vitamin D analog inhibits the reaction [VDR protein binds to CYP24A1 promoter]; Vitamin D analog promotes the reaction [[NCOR2 protein binds to VDR protein] which binds to CYP24A1 promoter]; Vitamin D analog promotes the reaction [NCOR2 protein binds to CYP24A1 promoter]; Vitamin D analog promotes the reaction [RXRA protein binds to CYP24A1 promoter]PMID:20055894 PMID:21917910
Cyp24a1multiple interactionsISOCyp24a1 (Mus musculus)6480464CTDEthanol promotes the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]PMID:22892342
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