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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:2716
Term: anethole
Definition: A monomethoxybenzene that is methoxybenzene substituted by a prop-1-en-1-yl group at position 4.
Chemical ID: MESH:C006578
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOEsr1 (Rattus norvegicus)6480464CTDanethole analog binds to ESR1 proteinPMID:27420082
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDanethole metabolite binds to ESR1 proteinPMID:12818366
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDanethole metabolite inhibits the reaction [Estradiol binds to ESR1 protein]PMID:12818366
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