GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cnr1 | affects binding | EXP | | 6480464 | CTD | anandamide binds to CNR1 protein | PMID:11408034 | Cnr1 | decreases expression | EXP | | 6480464 | CTD | anandamide results in decreased expression of CNR1 protein | PMID:31199905 | Cnr1 | increases activity | EXP | | 6480464 | CTD | anandamide results in increased activity of CNR1 protein | PMID:14504685 PMID:17557913 | Cnr1 | affects activity | ISO | CNR1 (Homo sapiens) | 6480464 | CTD | anandamide affects the activity of CNR1 protein | PMID:19147270 | Cnr1 | increases activity | ISO | CNR1 (Homo sapiens) | 6480464 | CTD | anandamide results in increased activity of CNR1 | PMID:10871313 | Cnr1 | increases response to substance | ISO | Cnr1 (Mus musculus) | 6480464 | CTD | CNR1 protein results in increased susceptibility to anandamide | PMID:29730318 | Cnr1 | multiple interactions | ISO | Cnr1 (Mus musculus) | 6480464 | CTD | [anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; [CNR1 protein affects the susceptibility to Chlorpyrifos] which affects the hydrolysis of anandamide; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]] | PMID:11891798 PMID:12657697 PMID:36858108 | Cnr1 | multiple interactions | ISO | CNR1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased activity of CNR1]; anandamide promotes the reaction [CNR1 protein affects the localization of ARRB2 protein]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Pertussis Toxin inhibits the reaction [anandamide results in increased activity of CNR1]; Rimonabant inhibits the reaction [anandamide results in increased activity of CNR1] | PMID:10871313 PMID:15453094 PMID:31024316 | | ||||||||||||||||||||||
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